• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention provides compounds of the formula <IMAGE> in which R is a hydrogen atom, a lower alkyl, lower alkenyl or aryl-lower alkyl group or the acyl radical of a lower alkyl-carboxylic acid or an aryl- carboxylic acid each having up to 10 carbon atoms; R1 is a hydroxy, lower alkoxy, di- (lower alkyl)-amino-lower alkoxy, amino, monosubstituted amino, disubstituted amino or dihydroxy-lower alkyl group; A and B together are a lower alkylene group of the formula (CH2)m-CH2-, a group of the formula <IMAGE> a group of the formula (CH2)ml- CH = CH or a disubstituted lower alkylene group of the formula <IMAGE> Z is sulphur or a sulphinyl or sulphonyl group; R' is a hydrogen atom or a lower alkyl group; R'' is a lower alkyl group; n is zero or 1; m is 1 or 2; m1 is zero, 1 or 2; and m2 is 1 or 2; and their diastereoisomers, optically active isomers and salts with inorganlc and organic bases. The invention also provides a process for preparing such compounds, and pharmaceutical compositions containing them. The compounds may be used in the treatment of hypertension.
    公开号:SU860696A1
    申请号:SU782704624
    申请日:1978-12-22
    公开日:1981-08-30
    发明作者:Мален Шарль；Роже Пьер；Лоби Мишель
    申请人:Сьянс Юньон Э Ко., Сосьете Франсэз Де Решерш Медикаль (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to the production of new derivatives of proline, which may find application in medicine.
    A reaction is known for producing amides from amines and acids in the presence of carbodiimide Г ^. The purpose of the invention is to develop, on the basis of the known method, a method for producing new compounds with valuable pharmacological properties.
    The cedar is achieved by the method of producing N-substituted butyramides of the general formula thiogde
    N-CO-CR-CH., - SR
    I 4
    CORj
    - hydrogen or acetyl;
    - hydroxyl or lower kil;
    together they mean ethylene or thioalkylene of the formula —CH — S — The said method consists in the action of “/.-trifluoromethylacrylic acid of the general formula on thiocarboxylic acid of the general formula where R is acetyl”
    CFj-C-COOH m and W 3 sn 2
    The resulting acetylthio-c <-trifluoromethylpropionic acid of the general formula
    RS-CH Z -CH-COOH £
    CF 3 where R is acetyl, is reacted with pyrrolidinylcarboxylic acid total
    I al
    formulas A20 IN - / h^ CORx 'where A and In have the above meanings reading - lower alkyl.
    The target product is obtained in free form or is converted into salt, or saponified, or hydrolyzed, or separated into diastereoisomers.
    The compounds of General formula I have 30 at least two asymmetric carbon atoms. Among diastereoisomers, erythro and threodiastereoisomers can be distinguished. The latter can be subdivided into their optical antipodes. Basically, anantiometric compounds have the configuration L.
    The separation of the diastereoisomers of the compounds of general formula I usually occurs by physical methods using chromatography in vapor and liquid phases at high pressure or by mutual saturation.
    The diastereoisomers are bifurcated into their optical antipodes mainly by salt formation of compounds of the general formula I, where R ^ is hydroxyl, using an optically active base, such as brucine, strychnine, spartein, ephedrine, <£ -treo 1-paranitrophenyl
    2-dimethylamine propane 1,3-diol, glucose amine or 1-streptamine.
    The compounds of general formula I, where R ^ is hydroxyl, give salts with a mineral or organic base, for example, sodium, potassium, lithium, ammonium, calcium, manganese, aluminum salts; alkylamine, for example methylamine, dimethylamine, methylethylamine, diisopropylamine or triethylamine; arylalkylamine, for example benzylamine, phenylethylamine; or methylbenzylamine j cycloalkylamine, for example cyclopropylamine or dicyclohexylamine, de (cycloalkyl) alkylamine, for example cyclopropylethylamine; aminosugar, for example glucosamine, mannosamine, methyl glucamine ^ amino acids, for example glycine or arginine.
    The method is as follows.
    The condensation between the trifluoromethylacrylic acid of the general formula III and the thiol of the general formula I I takes place in the presence or absence of a solvent at a temperature of about 0 °; condensation between (V-thio <£ -trifluoromethyl-propionic acid of the general formula IV and a carboxypyrrolidinyl acid of the general formula V in the presence of a carboxy activator such as dialkyl or dicycloalkylcarbodiimide, ethoxyacetylene or carbonyldiimidazole.
    The carboxypyrrolidinyl acid of general formula V is condensed with a derivative of formula IV using an ester, amide or its salt, and also C) -thio οί-trifluoromethylpropionic acid of general formula IV using a functional derivative of an acid of general formula IV, for example, acid halide, anhydride; mixed anhydride with ethyl chloroformate or lower alkyl ester;
    Partial saponification is carried out in a weak basic medium, for example, in the presence of a solution of ammonia, calcium hydroxide or barium hydroxide; general hydrolysis is carried out in an acidic medium, for example, in the presence of hydrochloric acid, sulfuric acid or perchloric acid in an aqueous medium.
    Example 1. 3-Dcetylthio-2-trifluoromethylpropionyl (L-pyrrolidinyl-2-ethylcarboxylate).
    Stage a.
    d L 3-Acetylthio-2-trifluoromethylpropionic acid.
    16.2 g of α-trifluoromethylacrylic acid, and then 8.75 g of thioacetic acid, are introduced into an ice bath balloon. Leave the contents for 15 min, maintaining the temperature of the reaction mixture at about 0 σ , then the mixture is distilled, the obtained main fraction is purified by fractional distillation at 145150 ° under a pressure of 15 mm and get
    21.4 g of d1-3-acetylthio-2-trifluoromethylpropionic acid.
    n ^ 2 = 1.433. The theoretical yield is 86%.
    Stage b.
    Df-3-acetylthio-2-trifluoromethylpropionic acid chloride.
    9.15 g of dl 3-acetylthio-2-trifluoromethylpropionic acid and 13 ml of freshly distilled thionyl chloride are mixed. It is heated under reflux for 3 hours, then distilled in vacuo to remove excess reagent and the resulting hydrochloric acid. The dry residue is purified by distillation in vacuo. Thus, 7.9 g of d1-3-acetylthio-2-trifluoromethyl-propionic acid chloride are obtained after distillation at 80-82 ^ 0 under a pressure of 16 mmHg. The yield is 80%.
    Found,%: C 15.22 Calculated,%: C 15.11 Stage c.
    dI - (3-acetylthio-2-trifluoromethylpropionyl) 1-pyrrolidinyl-2-carboxylate of ethyl and its epimers.
    In a three-necked flask equipped with a stirrer, 3.6 g of dl-3-acetylthio-2-trifluoromethylpropionic acid chloride are introduced into a solution of 20 ml of benzene, then 2.2 g of L-ethylprolinate in a solution of 20 ml of benzene. And 8.9 ml 2 M solution of triethylamine in benzene. The reaction mixture is stirred at a temperature of less than 5 ° C. for 12 hours. Then, the reaction medium is washed until the chlorine ions disappear. The organic phase is decanted, dried and evaporated to dryness in vacuo.
    Get dI - (3-acetylthio-2-trifluoromethylpropionyl) L-prop ion of t-ethyl in the form of a mixture of epimers with a yield of 95%.
    Found,%: C 44.95; H 5.23;
    N 4.3 3 H 4 & F % ° 4 NS = 341 '34
    Calculated,%: C 45.74} H 5.31, N 4.10.
    Separation of epimers is carried out by vapor phase chromatography in a non-polar column SEj o (height 1 m, temperature 150 ° C). Pure epimers are obtained by recrystallization in hexane. about
    Epimer 1: mp 74-78 C; ld / ^ at 578t / "38 ° 9’ (c = 1% ethanol) at 365 ^ 127 ° (c = 1% ethanol)
    Found,%: C 45.46 ’H 5.30;
    N, 4.12; S 9.36 s 19 n 4v F NO + S = 341.84
    Calculated,%: C 45.74; H 5.31; M 4.10; S 9.39;
    The NMR spectrum corresponds to the indicated structure (the presence of all expected protons).
    N- (3-Acetylthio-2-trifluoromethylpropionyl) 1-pyrrolidinyl-ethyl-2-carboxylate) (epimer 1) is a solid, soluble in organic solvents and insoluble in water.
    Example 2. N- (3-Acetylthio-2-trifluoromethylpropionyl) thiazolidinyl 4-methylcarboxylate.
    Acting as in stage B, according to example 1, but proceeding 4.68 g of chloride
    3-acetylthio-2-trifluoromethylpropionic acid and 2.95 g of thiaeolidinyl-4-methylcarboxylate (levorotatory isomer) give a dry residue weighing 5.7 g. For analysis, 2.8 g of a product sample is distilled under a pressure of 0.1 mmHg . The product is distilled at 152-164 ° C.
    A viscous, oily product is obtained, slightly yellowed.
    R
    N 22 = 1.5030
    Spectrum 1R: carbonyl band 1750 cm -4 ; carbonyl strip of thioether 1690 cm -4 ; 1660 cm ' 1 tertiary amide carbonyl tape
    Found,%: C 38.37 · H 4.16j N 4.26; S 18.64.
    H <4 NS 2 0 4 F s = 345.36
    Calculated,%: C 38.25 · H 4.08 ^ N 4.05; S 18.56.
    A mixture of epimers is obtained by vapor phase chromatography.
    Rotational ability (c = 1% methanol) at 5 78 m / i 70 5 ’546 νημ 80 ° 5 436 κψ 142 ° 3 365 mA” 241 ° 4
    Proton NMR spectrum from 5.3 to 4.4 ppm proton (CH,) - singlet at 3.8 ppm protons (array / at 3.3 ppm proton (CH t ) singlet at 2.4 ppm Example 3.N - ( 3-thio-2-trifluoromethylpropionyl) pyrrolidinyl-2-ethylcarboxylate.
    1.08 g of N - (3-acetylthio-2-trifluoromethylpropionyl) pyrrolidinyl ethyl carboxylate (mixture of epimers) is dissolved in 15 ml of water and 2 ml of 7 concentrated ammonium oxide hydrate. Stirred for 1 h at room temperature, add 20 ml of ice water, then leave for 1 h until precipitation. It is separated by filtration, dried, and then the aqueous phase is taken up in triplicate with ethyl acetate. The aqueous phase is decanted and evaporated to dryness in vacuo. The ammonium salt (3-thio-2-trifluoromethylpropionyl) pyrrolidinyl ethyl carboxylate is suspended in 80% alcohol and acidified with several ml of acetic acid. The solution was taken with ethyl acetate, then the solutions in ethyl acetate were separated, washed and dried to dryness in vacuo. The dry residue is recrystallized with a mixture of ethyl acetate - hexane.
    The yield is 51%.
    PRI me R 4.
    N- (3-Thio-2-trifluoromethylpropionyl)
    2-pyrrolidinyl-carboxylic acid. 2.7 g of K- (3-acetylthio-2-trifluoromethylpropionyl) pyrrolidinyl-2-ethylcarboxylate (mixture of epimers) in 25 ml of dioxane are suspended. Add
    1.5 ml of a methanol solution saturated with hydrochloric acid and the mixture is stirred for 12 hours at 0-5 ° C. It was then evaporated to dryness in vacuo and the residue was diluted with a mixture of ether and hexane. After filtration, the insoluble product was dissolved at high temperature in ethyl acetate. After that, 1.85 ml of dicyclohexylamine was added. By cooling, the salt of dicyclohexylamine N- (3-thio-2-trifluoromethylpropanoyl) pyrrolidinyl-2-carboxylic acid precipitates. It is separated by filtration, dried and purified by crystallization with isopropyl ether. The yield is 1.41 g.
    权利要求:
    Claims (4)
    [1]
    carbon atom. Among diastereoisomers, erythro and tridistereoisomers can be distinguished. The latter can be divided into their optical antipodes. In general, anantiometric compounds are of configuration L. The separation of diastereoisomers of compounds of general formula I is usually carried out by physical methods using chromatography in the vapor and liquid phases at high pressure or by mutual saturation. Splitting of the diastereoisomers into their optical antipodes occurs mainly by salt formation of the compound of the general formula I, where R is hydroxyl, with the help of an optically active base, such as brucine, strychnine, sparteine ephedrine, c6-threo 1-para-nitrophenyl 2-dimethylamine propane 1 , 3-diol, amine glucose or 1-streptamine. The compounds of general formula I, where R is hydroxyl, give salts with mineral or organic base, for example, sodium, potassium, lithium, ammonium, calcium, manganese, aluminum salts; alkylamine, for example methyl amine, dimethylamine, methylethylamine, diisopropylamine or triethylamine; aryl alkylamine, for example benzylamine, pheny ethylamine; or methylbenzylamine; alkylamine cycle, for example cyclopropylamine or dicyclohexylamine; de (cycloalkyl alkylamine, e.g. cyclopropylethyl amine; aminosugar, e.g. glucosamine, mannosamine, methylglucamine; amino acids, e.g. glycine or arginine. The process is carried out as follows. Condensation between cl-trifluoromethyl acrylic acid of general formula III and thiol of general formula II proceeds in the presence of the absence of a solvent at a temperature near condensation between III-thio-trnfluoromethylpropionic acid of general formula IV and carboxypyrrolidinyl acid of general formula V in the presence of a carboxyl activator of For example, dialkyl or di-cycloalkylcarbodiimide, ethoxyacetylene or carbonyldiimidazole. The carboxypyrrolidinyl acid of general formula V is condensed with the derivative of Formula IV using ether, amide or its salt, as well as with and -thio oi-trifluoromethylpropane in the same way as in the formula. hydrochloric acid of general formula IV, for example, an acid halide, anhydride, mixed anhydride with chlorofor ethyl or lower alkyl ether Partial saponification is performed in a weak basic medium, for example . in the presence of a solution of amgliac, calcium hydroxide or barium hydroxide, the total hydrolysis is carried out in an acidic medium, for example, in the presence of hydrochloric acid, sulfuric acid or perchloric acid in an aqueous medium. Example 1. Acetylthio-2-trifluoromethylpropionyl (L-pyrrolidinyl-2-ethylcarboxylate). Stage a. d L C-acetyl-thio-2-trifluoromethylpropionic acid. 16.2 g of trifluoromethylacrylic acid, and then 8.75 g of thioacetic acid are introduced into the ice bath balloon. Leave the contents for 15 minutes, keeping the temperature of the reaction mixture about. Then the mixture is distilled. the obtained main fraction was purified by fractional distillation at 145150 under a pressure of 15 mm, and 21.4 g of d1-3-acetylthio-2-trifluoromethylpropionic acid was obtained. 1,433. The theoretical yield is 86%. Stage b. Chloride d1-3-acetylthio-2-trifluoromethylpropionic acid. 9.15 g of dl 3-acetylthio-2-trifluoromethylpropionic acid and 13 ml of freshly distilled thionyl chloride are mixed. Heat the EO from reflux for 3 hours, then distill in vacuo to remove excess reagent and hydrochloric acid formed. The dry residue is distilled off in vacuo. Thus, 7.9 g of d1-3-acetylthio-2-trifluoromethyl-propionic acid chloride are obtained after distillation at 80-82 ° C under a pressure of 16 mm Hg. The yield is 80%. Found,%: C 15.22 Calculated,%: C 15.11 Stage c, dI - (3-acetylthio-2-trifluoromethylpropionyl) 1-pyrrolidinyl-2-carboxylate of ethyl and its epimers. In a three-necked flask equipped with a stirrer, 3.6 g of dl-3-acetylthio-2-trifluoromethylpropiono chloride are introduced. acid in a solution of 20 ml of benzene, then 2.2 g / L-ethyl prolinate in a solution of 20 ml of benzene and 8.9 ml of a 2 M solution of triethylamine in benzene. The reaction mixture is stirred at a temperature of less than 12 hours. Then the reaction medium is washed until the chlorine ions disappear. The organic phase is decanted, dried and evaporated to dryness under vacuum. The dI - (3-acetylthio-2-trifluoromethylpropionyl) L-propionate-ethyl is obtained as a mixture of epimers with a yield Found: C 44.95; H 5.23; N 4.33 M-fft O NS 341.34 Calculated,%: C 45.74) H 5.31, N 4.10. Epimer separation is carried out by chromatography in the vapor phase in a non-polar column SEj (height 1 m, temperature 150 s). Pure epimers are obtained by recrystallization in hexane. Epimer 1: mp 74-78 ° C; 578t 389 (with 1% ethanol) at 365t / 0127 ° (with 1% ethanol) Found: C 45.46; H 5.30; N 4.12; S 9.36 C., F, N04S 341.84 Calculated,%: C 45.74 H 5.31; M 4.10; S 9.39 The NMR spectrum corresponds to the indicated structure (the presence of all expected protons). N- (3-acetylthio-2-tryptermimethylpropionyl) 1-pyrrolidinyl ethyl-2-carboxylate) (epimer 1) is a solid substance that is soluble in physical solvents and insoluble in water. Example
    [2]
    2. N- (3-acetylthio-trifluoromethylpropionyl) -thiazolidine 4-methylcarboxylate. Acting as in stage 1 according to Example 1, but the outcome is 4.68 g of 3-acetylthio-2-trifluoromethylpropionic chloride and 2.95 g of thiazolidinyl methylcarboxylate (levorotatory isomer), and a dry residue of 5.7 g is obtained. For analysis, 2.8 g of a sample of the product is distilled under a pressure of 0.1 mm Hg. The product is distilled at 152-164 ° C. A viscous oily product is obtained, slightly tinted to yellow. N22 15030 Spectrum 1R: carbonyl band 1750 carbonyl band yew ether 1690 carbonyl bands of tertiary amide 1660 Found: C 38.37-H 4.16: N 4.26; S 18.64. C, 345.36 Calculated,%: C 38.25; H 4.08; N 4.05; S 18,56. A mixture of epimers is obtained by vapor chromatography. Rotational capacity (with 1 methanol) at 578 W / J 546 805, 436 m / J 142 ° 3 365 24l4 NMR spectrum of 3 protons from 5.3 to 4.4 rrhp 2 protons (CH,) - singlet at 3.8 5 protons (array / at 3.3 ppm 2 protons (CHt) singlet at 2.4 ppm Example
    [3]
    3. N- (3-thio-2-tref6pmethylpropionyl) pyrrolidinyl-2-ethylcarboxylate. 1.08 g of N- (3-acetylthio-2-trifluoromethylpropionyl) pyrrolidinyl ethylcarboxylate (mixture of epimers) is dissolved in 15 ml of water and 2 ml of 7 concentrated ammonium hydroxide. The mixture is stirred for 1 hour at room temperature, 20 ml of ice-cold water is added, then left to stand for 1 hour until precipitation occurs. It is separated by filtration, dried, and the aqueous phase is then taken up three times with ethyl acetate. The aqueous phase is decanted and evaporated to dryness in vacuo. The ammonium salt (3-thio-2-trifluoromethylpropionyl) pyrrolidinyl ethylcarboxylate is suspended in 80% alcohol and acidified with several ml of acetic acid. The solution is taken up in ethyl acetate, then the solutions in ethyl acetate are separated, washed, and dried to dryness in vacuo. The dry residue is recrystallized with a mixture of ethyl acetate - hexane. The yield is 51%. PRI me R
    [4]
    4. N- (3-thio-2-trifluoromethylpropionyl) 2-pyrrolidinyl carboxylic acid. 2.7 g of M- (3-acetylthio-2-trifluoromethylpropionyl) pyrrolidinyl-2-ethylcarboxylate (mixture of epimers) are suspended in 25 ml of dioxane. 1.5 ml of a methanolic solution saturated with hydrochloric acid are added and the mixture is stirred for 12 hours at 0-5 seconds. It is evaporated to dryness in vacuo and the residue is diluted with a mixture of ether and hexane. After filtration, the insoluble material is dissolved in ethyl acetate at a high temperature. After that, 1.85 ml of dicyclohexylamine is added. By cooling, the salt of dicyclohexylamine N- (3-thio-2-trifluoroethylpropanoyl) pyrrolidinyl-2-carboxylic acid precipitates. It is separated by filtration, dried and purified by crystallization with isopropyl ether. The yield is 1.41 g. Claim 1. A method for producing N-substituted iobutyramides of the general formula I G —Co-cn-ac-a COR, CPj where ft is hydrogen or acetyl; R is hydroxyl or lower alkyl; A and B together represent ethylene or thioalkylene of the formula —CHj.-S-,
    characterized in that a thiocarboxylic acid of general formula I I
    RSH,
    where R is acetyl,
    act about trifluoromethyl acrylic
    acid of general formula III
    SGS C-COOH CHj
    the acetylthio-oi-trifluoromethylpropionic acid thus obtained by the formula IV
    RS-CHi CH-COOH
    b.
    where R is acetyl,
    translated into functional function by carboxyl group and condensed with pyrrolidinylcarboxylic acid into racemic or optically active form of general formula V
    COR,
    WHEREAS A and B have the above values -
    R is lower alkyl
    and the target product is either isolated in a free form, or saponified by the action of a mineral acid, or partially hydrolyzed in the basic medium, or salified when R is hydrogen, or separated into diastereoisomers by a physical or chemical method.
    Sources of information taken into account during the examination 1. Buhler K., Pearson D, Organic syntheses, Part 2, p. 384 and next, 1973.
    类似技术:
    公开号 | 公开日 | 专利标题
    Anderson et al.1952|Tetraethyl Pyrophosphite as a Reagent for Peptide Syntheses1
    DK159680B|1990-11-19|CYCLIC IMIDES USED FOR THE PREPARATION OF CYCLIC AMINO ACIDS
    Fitt et al.1977|. alpha.-Alkylation and Michael addition of amino acids-a practical method
    SU860696A1|1981-08-30|Method of preparing n-substituted thiobutyramides or their salts
    FI113766B|2004-06-15|Process for the preparation of | cis-beta-phenylglycidic acid
    BR112019023582A2|2020-06-02|METHOD OF PREPARING | -3-ACETAMIDO-4-ALYL-N- | PIRROLIDIN-3-CARBOXAMIDE
    US5883121A|1999-03-16|Epoxysuccinamide derivative or salt thereof, and medicine comprising the same
    SU837319A3|1981-06-07|Ne or their salts
    KR100491633B1|2005-09-09|3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives
    SU448639A3|1974-10-30|The method of obtaining amino-alcohol derivatives of o-trans-hydroxycinnamic acid
    US5886046A|1999-03-23|Dicarbonyl-containing compounds
    Cannon et al.1970|Small ring analogs of acetylcholine. Synthesis and absolute configurations of cyclopropane derivatives
    SU508176A3|1976-03-25|Method for preparing amino derivatives of benzophenone
    JP3843464B2|2006-11-08|Method for producing γ-mercaptocarboxylic acid derivative
    KR100224330B1|1999-10-15|N- 4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl)carbonyl)amino acids
    SU728712A3|1980-04-15|Method of preparing cinnamoyl amide
    SU803859A3|1981-02-07|Method of preparing omega-thiopropionamides or their acid-additive salts
    SU439978A1|1974-08-15|The method of obtaining sulfamoylpyrimidine or its salt
    SU463676A1|1975-03-15|The method of obtaining 0,0-diaryl-1aryloxyacyloxy-2,2,2-trichloroethylphosphonate
    TW202116727A|2021-05-01|N-formylhydroxylamines as neprilysin | inhibitors, in particular as mixed aminopeptidase n | and neprilysin | inhibitors
    US4923888A|1990-05-08|Butenoic acid amides, their salts, and pharmaceutical compositions containing them
    EP0470702B1|1995-09-27|An optically active morpholino oxobutyric acid hydroxy binaphthalene derivative and its preparation
    KR950013082B1|1995-10-24|Process for making and isolating |-2-hydroxy-4-phenylbutyric acid and ester
    SU359811A1|Method of producing halogen aminocarboxy derivatives
    FI59793C|1981-10-12|MELLAN PRODUCTS FOR FRAMSTATION PROCESSING OF HETEROCYCLIC BENZAMIDES WITH PHARMACOLOGICAL ACTIVITIES OR
    同族专利:
    公开号 | 公开日
    GB2014132B|1982-08-11|
    SE7813180L|1979-06-23|
    OA06139A|1981-06-30|
    FR2412537B1|1981-10-16|
    ZA787196B|1979-11-28|
    GB2014132A|1979-08-22|
    IT1158184B|1987-02-18|
    IT7852406D0|1978-12-21|
    ES476314A1|1979-04-16|
    PT68966A|1979-01-01|
    DD142545A5|1980-07-02|
    BE872972A|1979-06-21|
    FR2412537A1|1979-07-20|
    AR222815A1|1981-06-30|
    DE2854877A1|1979-06-28|
    GR66839B|1981-05-04|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    AU509899B2|1976-02-13|1980-05-29|E.R. Squibb & Sons, Inc.|Proline derivatives and related compounds|
    US4052511A|1976-02-13|1977-10-04|E. R. Squibb & Sons, Inc.|Carboxyacylproline derivatives|CA1109475A|1978-07-27|1981-09-22|Squibb& Sons, Inc.|Thiopropanoylamino acid derivatives|
    US4483861A|1978-10-31|1984-11-20|Santen Pharmaceutical Co., Ltd.|Antihypertensive sulfur-containing compounds|
    ZA802420B|1979-05-18|1981-04-29|Squibb & Sons Inc|Aminoacyl derivatives of mercaptoacyl amino acids|
    ZA802709B|1979-05-30|1981-05-27|Merrell Toraude & Co|N-acyl-amino acid derivatives|
    US4284561A|1979-12-03|1981-08-18|E. R. Squibb & Sons, Inc.|Hydroxamic acid derivatives of mercaptoacyl amino acids|
    US4308392A|1979-12-03|1981-12-29|E. R. Squibb & Sons, Inc.|Hydroxamic acid derivatives of mercaptoacyl amino acids|
    JPH0140030B2|1979-12-13|1989-08-24|Santen Pharma Co Ltd|
    JPS6241600B2|1980-04-02|1987-09-03|Santen Pharma Co Ltd|
    US4482725A|1980-04-03|1984-11-13|E. R. Squibb & Sons, Inc.|S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR7738728A|FR2412537B1|1977-12-22|1977-12-22|
    [返回顶部]